21^st Global Obesity Meeting

Biography

Biography: Hongkai Gao

Abstract

Obesity is a major public health problem worldwide. Roux-en-Y Gastric Bypass (RYGB) is the most effective bariatric surgery approach that has been shown to induce considerable weight loss and improve metabolic parameters in obese patients. In view of the increasing adoption of metabolic surgery, post-surgical follow-ups are important to assess long-term effects and efficacy.Therefore, the aim of this study is to report on time changes on non-morbid patients in adiposity, insulin secretion and sensitivity, glucose homeostasis and improvement in diabetes after Roux-en-Y Gastric Bypass (RYGB) surgery in Chinese ethnicity. This prospective cohort study involved 177 patients who met the indications of bariatric surgery for obesity. Markers of adiposity, insulin secretion and sensitivity, glucose homeostasis and diabetes control were monitored from baseline to 12 months in all participants and up to five years in a subset of participants. Mixed-linear and logistic regression models were used for follow up. Mean BMI decreased by 15.5% from 30.31±5.21 kg/m² at baseline to 25.33±2.57 kg/m² at 12 months (p<0.001). Indices of insulin secretion and c-peptide improved during follow-up, translating into improved insulin sensitivity and glucose homeostasis. Improved diabetes control (HbA1c<6.5%) among those with diabetes was 64% at six months and 67.2% at 12 months, then the percentage of diabetes control dropped smoothly since three years (62.7%) after surgery to 5 years (60.5%). Findings were mostly similar in men and women. The favorable effects of RYGB over time on total adiposity in this population were paralleled by significant improvement in insulin secretion and sensitivity and glucose tolerance.