Hongkai Gao
Chinese PLA General Hospital, China
Title: Effect of laparoscopic gastric bypass on body fat distribution and expression of adiponectin, leptin in obesity patients with T2DM
Biography
Biography: Hongkai Gao
Abstract
Obesity and its complications, such as diabetes have become a major health problem. Roux-en-Y Gastric Bypass (RYGB) is the most effective bariatric surgery approach that has been shown to induce considerable weight loss and improve metabolic parameters in obese patients. Therefore, the aim of this study is to evaluate changes in abdominal fat distribution, adiponectin, leptin and its relationship with diabetes remission following laparoscopic RYGB in obesity patients with T2DM. Body fat distribution by Tanita Body Composition Analyzer (Tanita Corporation, Tokyo, Japan) and Quantitative CT (QCT), adiponectin, letptin, insulin secretion and sensitivity, glucose homeostasis and diabetes control were monitored from baseline to 12 months in 52 obese patients with T2DM after RYGB. During the one-year follow-up, the remission rate of T2DM was 86.5% (45/52) and obesity was 67.3% (35/52). Then, Adiponectin decreased slightly in three months follow-up and increased gradually to 12 months after surgery while leptin increased gradually after surgery till 12 months. Body composition analyzer show fat mass and free fat mass decreased significantly after surgery, while fat mass changed more sharply. The total abdominal fat volume decreased significantly following surgery. Futhermore, total visceral fat volume contributed more fat loss than total subcutaneous fat volume and the visceral fat lost most in L5/S1 level by QCT. Abdominal visceral fat accumulation is a pathogenic factor of metabolic disorder which contributes to obesity and diabetes. The improvement of abdominal fat distribution and adipokines functions might be one of the main metabolic reasons of diabetes remission after RYGB.