Mirey Karavetian
Zayed University, UAE
Title: Association between β-amino-isobutyric acid and cardiometabolic risk
Biography
Biography: Mirey Karavetian
Abstract
Physical activity protects from the development of chronic diseases. Preclinical studies suggest that circulating levels of the myokine β-amino-isobutyric acid (BAIBA) may prevent obesity and improve cardiometabolic health. We aimed at assessing among healthy young individuals whether serum BAIBA is associated with physical activity, markers of cardiometabolic risk, and whether gender differences exist. The design was cross-sectional, conducted on 80 university students.
Anthropometry, blood pressure, lipid profile, blood glucose, C-reactive protein, cortisol and physical activity were measured and analyzed against serum BAIBA levels.
Mean age of the sample was 19.3 ±2.0 years. BAIBA levels were 1.57±0.61 mM. Males had significantly larger waist (86.0±9.6 cm), systolic and diastolic blood pressure (124.9±11.7 mmHg and 77.9±9.9 mmHg, respectively), fasting blood glucose (84.6±7.5 mg/dL), cortisol (594.8±158.9 nmol/L) and physical activity levels than females. They also had significantly lower HDL (46.9±7.3 mg/dL). BAIBA concentrations in males and females were not significantly different. No significant association was found between BAIBA concentrations and nutritional, metabolic and functional parameters, except for diastolic blood pressure (DBP) in males (P=0.03). BAIBA in males predicted DBP as disclosed by ROC curve analysis. The BAIBA value of 0.97µM was estimated as the best predictive value in distinguishing normotensive DBP in males whereby lower levels would distinguish higher diastolic blood pressure.
In conclusions; among healthy, young individuals, serum BAIBA levels were not related to nutritional status, metabolic status, and physical activity, but they were inversely related to DBP in males only.